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Surrogate Model Development for Digital Experiments in Welding
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Implementation of the INTERGROWTH-21st Project in the UK.

F Roseman1, H E Knight, F Giuliani

  • 1Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK Dipartimento di Scienze Pediatriche e dell'Adolescenza, Cattedra di Neonatologia, Università degli Studi di Torino, Torino, Italy.

BJOG : an International Journal of Obstetrics and Gynaecology
|May 18, 2013
PubMed
Summary

The International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) project in Oxfordshire successfully recruited participants despite challenges. Meticulous planning ensured high data quality and improved clinical care standards.

Keywords:
Fetal growthINTERGROWTH-21stnutritionstandards

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Area of Science:

  • Maternal and Child Health
  • Clinical Research Methodology
  • Epidemiology

Background:

  • Oxfordshire, UK, hosts a European site for the INTERGROWTH-21st Project, a global initiative studying fetal and newborn growth.
  • The John Radcliffe Hospital, serving over 75% of Oxfordshire's deliveries, was the primary recruitment site for the Fetal Growth Longitudinal Study (FGLS) and Newborn Cross-Sectional Study (NCSS).

Purpose of the Study:

  • To implement and assess the feasibility of large-scale fetal and newborn growth studies within a UK healthcare setting.
  • To overcome recruitment and data collection challenges in a demanding research project.
  • To evaluate the impact of such studies on clinical care standards.

Main Methods:

  • Recruitment strategies included forming a research coalition and distributing information leaflets to antenatal care patients.
  • Data collection involved overcoming challenges related to maternal ineligibility criteria (age, smoking, BMI) for FGLS.
  • Ensuring timely anthropometric data collection for NCSS before early discharge of newborns was a key logistical challenge.

Main Results:

  • Despite challenges like maternal ineligibility and rapid newborn discharge, recruitment targets were met.
  • High standards of data quality were maintained throughout the project.
  • The study demonstrated that large-scale clinical research can be well-received and integrated without disrupting routine care.

Conclusions:

  • Meticulous planning and integration with routine clinical care are crucial for the success of large-scale health studies.
  • The INTERGROWTH-21st Project in Oxfordshire successfully navigated implementation challenges.
  • Such research initiatives can positively contribute to improving the overall standard of clinical care.