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Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: May 11, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

EZH2: an epigenetic gatekeeper promoting lymphomagenesis.

Holger Heyn¹, Manel Esteller

¹Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain.

|May 18, 2013

Summary

Germinal center-derived neoplasms are addicted to EZH2 activity, a key regulator of B cell activation. Targeting this reversible process offers a promising new avenue for lymphoma therapy.

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

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Published on: March 27, 2020

Area of Science:

Oncology
Immunology
Epigenetics

Background:

B cell activation is a complex process involving epigenetic regulation.
Germinal center-derived neoplasms, such as lymphomas, often hijack cellular pathways for survival and proliferation.

Purpose of the Study:

To investigate the role of Enhancer of Zeste Homolog 2 (EZH2) in B cell activation and germinal center-derived neoplasms.
To explore the therapeutic potential of targeting EZH2 activity in lymphoma.

Main Methods:

The study likely involved molecular biology techniques to assess EZH2 function in B cells.
Analysis of germinal center-derived neoplasms to identify EZH2 dependency.

Main Results:

EZH2 was identified as an essential regulator of B cell activation.
Germinal center-derived neoplasms exhibit a specific addiction to EZH2 activity.
This dependency represents a reversible process.

Conclusions:

EZH2 is a critical target for B cell activation and a vulnerability in germinal center-derived neoplasms.
Targeting EZH2 offers significant translational value for developing novel lymphoma therapies.