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Updated: May 11, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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EZH2: an epigenetic gatekeeper promoting lymphomagenesis
1Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain.
Abstract:
In this issue of Cancer Cell, Béguelin and colleagues highlight EZH2 as an essential regulator for B cell activation and report an addiction of germinal center-derived neoplasms to EZH2 activity. This reversible process is specifically targetable and hence presents high translational value for lymphoma therapy.
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