Related Experiment Video

Updated: May 11, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

What's new in pediatric dermatology?: part I. Diagnosis and pathogenesis

Howard B Pride1, Megha Tollefson, Robert Silverman

  • 1Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania 17822-5206, USA. hpride@geisinger.edu

Journal of the American Academy of Dermatology
|May 18, 2013
PubMed

Insights

This review highlights recent advancements in pediatric dermatology, covering new diagnoses and insights into the causes and development of common and rare skin conditions in children.

Area of Science:

  • Pediatric Dermatology
  • Dermatology
  • Genetics

Background:

  • The field of pediatric dermatology is rapidly evolving with new discoveries.
  • Understanding the etiology and pathogenesis of pediatric skin disorders is crucial for effective management.

Purpose of the Study:

  • To review recent developments in pediatric dermatology.
  • To discuss new diagnoses and insights into the pathogenesis of various pediatric skin disorders.

Main Methods:

  • Literature review of recent advancements in pediatric dermatology.
  • Synthesis of new findings on the etiology and pathogenesis of pediatric skin conditions.

Main Results:

  • Discussion of atopic dermatitis pathogenesis, new contact dermatitis forms, and port wine stain mimics.
  • Exploration of infantile hemangioma associations, RASopathies, and mosaic disorders.
  • Inclusion of cystic fibrosis-associated palm wrinkling, new epidermolysis bullosa types, and genital ulcers in adolescents.

Conclusions:

  • Recent advancements offer improved understanding and potential for novel therapeutic strategies in pediatric dermatology.
  • This review provides a foundation for further research and clinical practice in managing pediatric skin conditions.

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Introduction to Language of Pathophysiology l01:25

Introduction to Language of Pathophysiology l

Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...