Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isosulfan blue sentinel lymph node biopsy enables reliable lymph node harvest and multicolor flow cytometry in mice.

Journal of immunological methods·2026

Same author

Physical continuity at biomaterial-ECM interfaces is associated with reduced fibroblast activation and NF-κB signaling.

Biomaterials·2026

Same author

Lipidomic signatures of CNS ischemic injury and their modulation by immunomodulatory hydrogels.

The Analyst·2026

Same author

Physical continuity at biomaterial-ECM interfaces regulate fibroblast activation via NF-κB.

bioRxiv : the preprint server for biology·2026

Same author

Coupling computational fluid dynamics and kinetic models using a compartmental model applied to a full-scale agricultural digester.

Journal of environmental management·2026

Same author

Co-delivery of synaptogenic and angiogenic nanoparticles in MAP scaffolds enhances post-stroke synapse formation.

Journal of materials chemistry. B·2026

Same journal

Upcycling food processing byproducts via advanced yeast fermentation.

Current opinion in biotechnology·2026

Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026

Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026

Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026

Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026

Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 11, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Matrix-based gene delivery for tissue repair.

Cynthia Cam¹, Tatiana Segura

¹Department of Bioengineering, University of California, Los Angeles, United States.

Current Opinion in Biotechnology

|May 18, 2013

Summary

This summary is machine-generated.

Gene delivery into tissue repair scaffolds offers tunable, long-lasting therapeutic protein production. Scaffold design significantly impacts gene expression and tissue regeneration outcomes.

More Related Videos

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Related Experiment Videos

Last Updated: May 11, 2026

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

Area of Science:

Biomaterials Science
Regenerative Medicine
Molecular Biology

Background:

Tissue repair scaffolds require structural and biochemical cues for effective regeneration.
Gene delivery offers advantages over protein delivery, including tunable expression and sustained therapeutic protein production via cellular machinery.
This approach activates autocrine and paracrine signaling pathways crucial for tissue formation.

Purpose of the Study:

To review the critical role of scaffold design in tissue engineering for regenerative medicine.
To explore how scaffold design parameters influence transgene expression and subsequent tissue repair.
To highlight gene delivery as a superior alternative to protein delivery in tissue repair scaffolds.

Main Methods:

Literature review focusing on scaffold design principles in tissue engineering.
Analysis of studies investigating gene delivery methods within biomaterial scaffolds.
Examination of the impact of material properties, architecture, vector incorporation, and biochemical cues on biological outcomes.

Main Results:

Scaffold material, architecture, and vector incorporation strategies directly affect transgene expression levels and duration.
Biochemical cue presentation within scaffolds modulates cellular responses and enhances tissue regeneration.
Gene delivery enables sustained therapeutic protein production, leading to improved tissue repair compared to traditional protein delivery.

Conclusions:

Optimized scaffold design is paramount for successful gene delivery and tissue regeneration.
Gene-incorporating scaffolds represent a promising strategy for advanced regenerative medicine applications.
Further research into scaffold parameters can unlock the full potential of gene therapy for tissue repair.