Antithrombotic activity of an unsaturated fatty acid preparation

An unsaturated fatty acid preparation from fish oil, "Epavit", completely prevented arterial thrombosis induced in the rat aorta by a combined stenosis, extensive endothelial perturbation and i.v. serotonin, at an optimum dose of 0.1 ml/200 g orally. A partial effect lasted more than 18 hours. After repeated administrations the acute completely inhibitory effect was decreased but the partial and chronic one remained unchanged. Aspirin (ASA) showed no synergic activity. Venous thrombosis (one-sided ligature of the caval vein combined with extensive endothelial perturbation) was inhibited to a similar degree as arterial thrombosis. Epavit also prevented the destabilizing effect of i.v. citrate on the endothelial lining.