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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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Related Experiment Video

Updated: May 11, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Polysaccharide-based nucleic acid nanoformulations.

Koen Raemdonck1, Thomas F Martens, Kevin Braeckmans

  • 1Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.

Advanced Drug Delivery Reviews
|May 18, 2013
PubMed
Summary
This summary is machine-generated.

Natural polysaccharides offer biocompatible solutions for creating advanced nanomedicines. These materials enhance the safe and efficient intracellular delivery of nucleic acids, overcoming biological barriers for improved therapeutic outcomes.

Keywords:
ChitosanCyclodextrinDextranGene therapyHyaluronic acidNanomedicinePlasmid DNAsiRNA

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Last Updated: May 11, 2026

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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery

Background:

  • Nucleic acid therapeutics require effective intracellular delivery systems.
  • Nanoparticles (nanomedicines) face biological barriers hindering drug delivery.
  • Biocompatible materials are crucial for designing safe and efficient nanocarriers.

Purpose of the Study:

  • To review the use of natural polysaccharides in nucleic acid nanocarrier design.
  • To summarize recent advancements in polysaccharide-assisted nucleic acid delivery.
  • To critically discuss the benefits of polysaccharides for improving nanomedicine delivery.

Main Methods:

  • Literature review of polysaccharides and their derivatives in nanomedicine.
  • Analysis of polysaccharide-based nanocarrier systems for nucleic acid delivery.
  • Discussion of challenges and opportunities in polysaccharide-assisted delivery.

Main Results:

  • Various polysaccharides and their derivatives are employed in nucleic acid nanocarrier development.
  • Polysaccharides offer inherent biocompatibility and tunable properties for nanocarrier formulation.
  • Recent progress shows promise in overcoming delivery barriers using these biopolymers.

Conclusions:

  • Natural polysaccharides are promising candidates for developing advanced nucleic acid delivery systems.
  • Strategic design of polysaccharide-based nanomedicines can enhance therapeutic efficacy.
  • Further research into polysaccharide-assisted delivery holds significant potential for future therapeutics.