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Related Experiment Video

Updated: May 11, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Recent advances in microfluidic techniques for single-cell biophysical characterization.

Yi Zheng1, John Nguyen, Yuan Wei

  • 1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.

Lab on a Chip
|May 18, 2013
PubMed
Summary
This summary is machine-generated.

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Biophysical properties of cells offer insights into health and disease. This review explores microfluidic tools for high-throughput single-cell biophysical characterization, addressing current technical challenges.

Area of Science:

  • Biophysics
  • Cell Biology
  • Biotechnology

Background:

  • Cellular biophysical properties (mechanical, electrical) are crucial for biological regulation.
  • These properties can serve as label-free biomarkers for cell physiological states and diseases.
  • Existing research tools face challenges in high-throughput, robust, and user-friendly single-cell biophysical measurements.

Purpose of the Study:

  • To review emerging microfluidic technologies for single-cell biophysical characterization.
  • To compare different microfluidic techniques for biophysical measurements.
  • To discuss the technical details, advantages, and limitations of these devices.

Main Methods:

  • Review of scientific literature on microfluidic devices for cell biophysics.

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Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

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Last Updated: May 11, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

  • Comparative analysis of various microfluidic techniques.
  • Discussion of technical aspects, benefits, and drawbacks of selected tools.

    • Main Results:

    • Identification of several microfluidic approaches for single-cell biophysical analysis.
    • Comparison of techniques based on throughput, robustness, and ease of use.
    • Detailed examination of the strengths and weaknesses of different microfluidic platforms.

    Conclusions:

    • Microfluidic technologies show significant promise for advancing single-cell biophysical characterization.
    • Overcoming technical challenges is key to realizing the full potential of these tools.
    • Further development is needed for widespread adoption in disease diagnostics and research.