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Improvement of radioactive colloid binding by tumor cells
L J Anghileri1, C Marchal, P Maincent
1Laboratory of Biophysics, Faculty of Medicine, University of Nancy, France.
Tumori
|June 30, 1990
Abstract:
Treatment of P388 leukemia cells with poly-DL-lysine (Poly-lys) considerably increases the binding of colloidal chromic phosphate (32P). This augmentation of the number of particles that are bound is in direct relationship with Poly-lys concentration, and very significantly with its degree of polymerization. Treatment with Poly-lys molecular weight 77,000 shows a 100% increase of binding with 200 micrograms and of 50% with 100 micrograms. Poly-lys M.W. 8,000 presents no significant increase, and for the other molecular weights the binding is intermediate.