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Updated: May 11, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄@SiO₂ for simultaneous tumor cell targeting and
Feng Wang1, Giovanni M Pauletti, Juntao Wang
1Materials Science and Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA.
Abstract:
Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3 O4 @SiO2 and polystyrene surfaces of a unique polystyrene/Fe3 O4 @SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments.
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