Related Experiment Video

Updated: May 11, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Association between hs-CRP and Hba1c in overweight type 2 diabetic female patients

Veerasak Sarinnapakorn1, Warangkana Wanicagool

  • 1Department of Medicine, College of Medicine, Rajavithi Hospital, Rangsit University, Bangkok, Thailand. veerasak_sarin@yahoo.co.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|May 21, 2013
PubMed

Insights

High-sensitive C-reactive protein (hs-CRP) is linked to higher HbA1c levels in overweight women with type 2 diabetes. Elevated hs-CRP (≥1 mg/L) indicates a significant increase in mean HbA1c, suggesting a correlation between inflammation and glycemic control.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • High-sensitive C-reactive protein (hs-CRP) is a marker for atherosclerosis.
  • Previous research links hs-CRP to insulin resistance, type 2 diabetes, and elevated HbA1c.
  • Type 2 diabetes is prevalent in overweight women, necessitating investigation into hs-CRP and HbA1c relationships in this demographic.

Purpose of the Study:

  • To investigate the relationship between hs-CRP levels and HbA1c in overweight women with type 2 diabetes.
  • To determine if hs-CRP levels correlate with glycemic control (HbA1c) in this specific patient group.

Main Methods:

  • Retrospective study of 75 female type 2 diabetic patients (age ≥40, BMI >25 kg/m²) at Rajavithi Hospital (Jan 2009–June 2011).
  • Collected blood samples to measure hs-CRP and HbA1c levels.
  • Patients were categorized into two groups based on hs-CRP levels: <1 mg/L and ≥1 mg/L.

Main Results:

  • A significant correlation was observed between hs-CRP levels and HbA1c.
  • Patients with hs-CRP levels ≥1 mg/L exhibited higher mean HbA1c (8.77 ± 1.78%) compared to those with hs-CRP <1 mg/L (7.36 ± 1.23%).
  • This difference was statistically significant (p < 0.001).

Conclusions:

  • hs-CRP levels are correlated with HbA1c levels in overweight women with type 2 diabetes.
  • Mean HbA1c levels are significantly higher in patients with hs-CRP levels of 1 mg/L or more.
  • Factors like age, blood pressure, BMI, LDL-C, and serum creatinine did not show a correlation with hs-CRP levels in this study.
Abstract

Related Concept Videos

Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...