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Updated: May 11, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

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Published on: January 28, 2020

Predictive value of elevated cystatin C in patients undergoing primary angioplasty for ST-elevation myocardial

Ozgur Akgul1, Huseyin Uyarel, Mehmet Ergelen

  • 1Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Istanbul, Turkey 34303.

Journal of Critical Care
|May 21, 2013
PubMed

Insights

High cystatin C levels in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary PCI predict higher mortality. This finding highlights cystatin C as a key prognostic marker for STEMI outcomes.

Area of Science:

  • Cardiology
  • Biomarkers
  • Acute Coronary Syndromes

Background:

  • Cystatin C (CysC) prognostic value is known in non-ST-elevation acute coronary syndromes.
  • Its role in ST-segment elevation myocardial infarction (STEMI) requires further clarification.

Purpose of the Study:

  • To assess the prognostic significance of CysC in STEMI patients.
  • To evaluate CysC as a predictor of outcomes after primary percutaneous coronary intervention (PCI).

Main Methods:

  • Prospective enrollment of 475 STEMI patients undergoing primary PCI.
  • Tertile-based grouping of patients by admission CysC levels (high CysC >1.12 mg/L).
  • Analysis of clinical characteristics and in-hospital/1-month outcomes.

Main Results:

  • Higher CysC group was older and showed significantly increased in-hospital and 1-month cardiovascular mortality.
  • Admission CysC >1.12 mg/L independently predicted 1-month cardiovascular mortality (OR 5.3, P=.02).

Conclusions:

  • Elevated admission CysC levels are associated with worse outcomes in STEMI patients.
  • CysC is a valuable prognostic marker for cardiovascular mortality post-primary PCI in STEMI.
Abstract

Keywords:
Cystatin CPrimary angioplastyST elevation myocardial infarction

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