Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimization of seeding cell density for differentiation of adipose-derived stem cells into epithelial-like cells on bioengineered composite scaffolds.

Differentiation; research in biological diversity·2025
Same author

Cell type specific differences in transcriptome profiles of adipose derived stem cells and vaginal fibroblasts in patients with pelvic organ prolapse.

Gene·2025
Same author

Idiopathic Subglottic Stenosis Is Associated With More Frequent and Abnormal Squamous Metaplasia.

The Annals of otology, rhinology, and laryngology·2023
Same author

Regenerating airway epithelium using fibrous biomimetic basement membranes.

Journal of biomedical materials research. Part A·2022
Same author

A Tissue Engineered Construct for Laryngeal Regeneration: A Proof-of-Concept Device Design Study.

The Laryngoscope·2022
Same author

Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study.

Stem cell research & therapy·2022

Related Experiment Video

Updated: May 11, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Sex dimorphism and depot differences in adipose tissue function.

Ursula A White1, Yourka D Tchoukalova1

  • 1Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.

Biochimica Et Biophysica Acta
|May 21, 2013
PubMed
Summary
This summary is machine-generated.

Excessive body fat increases metabolic disease risk. Fat distribution, particularly upper-body versus lower-body fat, significantly impacts metabolic health and requires further investigation into its depot- and sex-dependent functions.

Keywords:
AdipogenesisAdipokineAdipose tissueFat distributionFatty acidsLipolysis

More Related Videos

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Related Experiment Videos

Last Updated: May 11, 2026

Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Area of Science:

  • Metabolic science
  • Endocrinology
  • Obesity research

Background:

  • Obesity, defined by excess adiposity, is a significant risk factor for metabolic diseases like type 2 diabetes mellitus (T2DM).
  • Adipose tissue distribution, more than overall adiposity, is increasingly recognized as a key determinant of metabolic health.
  • Upper-body fat accumulation is linked to adverse metabolic complications, whereas lower-body fat may confer metabolic protection.

Purpose of the Study:

  • To review and highlight depot- and sex-dependent differences in white adipose tissue function.
  • To elucidate mechanisms regulating fat distribution in men and women.
  • To explore variations in adipogenesis, developmental patterning, fatty acid storage/release, and secretory functions across different adipose depots.

Main Methods:

  • Literature review of current research on adipose tissue function and distribution.
  • Analysis of studies investigating sex- and depot-specific characteristics of white adipose tissue.
  • Synthesis of findings related to adipogenesis, fat storage, and endocrine functions.

Main Results:

  • White adipose tissue function varies significantly based on anatomical location (depot) and sex.
  • Upper-body adipose depots exhibit distinct metabolic and secretory profiles compared to lower-body depots.
  • These differences influence the overall metabolic impact of obesity.

Conclusions:

  • Understanding depot- and sex-specific adipose tissue biology is crucial for comprehending obesity-related metabolic pathologies.
  • Targeting specific adipose depots or pathways may offer novel therapeutic strategies for metabolic diseases.
  • Further research into the regulation of fat distribution is warranted.