[The clinico-immunological parallels in patients with anthroponotic trichophytosis]

Studies of the lymphocytic and neutrophilic rosette formation, measurements of the levels of immunoglobulins A, M, and G, as well as of the neutrophil phagocytic activities, and determination of the nonspecific defense factors in patients with anthroponotic trichophytosis have helped estimate the immune status disorders and contribution of these disorders to the development of clinical manifestations in these patients. A relationship was detected between the intensity of rosette formation and the clinical form of the disease, duration of the skin process, patient's age, this evidencing the significance of these factors in the pathogenesis of anthroponotic trichophytosis. The patterns of immune shifts vary in the examined groups; the authors consider that this fact is related to the body reactivity, status of natural immune defense, concomitant diseases, and clinical forms of trichophytosis. Patients with chronic condition develop the most manifest changes in the immune status. This form of anthroponotic trichophytosis appears to involve essential disorders of adaptive immune mechanisms. Basing on the detected immunity shifts, the authors have defined the indications for, and substantiated the choice of adequate therapeutic immunomodulators in combined therapy of the condition. Immunity correction is not recommended for clinical and immunological Group 4 patients, but is obligatory for Groups 1, 2, and 3 patients.