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Updated: May 11, 2026
08:30
Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
TH2, allergy and group 2 innate lymphoid cells
Paula Licona-Limón1, Lark Kyun Kim, Noah W Palm
1Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Nature Immunology
|May 21, 2013
Summary
Type 2 innate lymphoid cells (ILC2s) are crucial for initiating type 2 immune responses. Understanding ILC2 cell biology may lead to new treatments for allergies and parasitic infections.
Area of Science:
- Immunology
- Cell Biology
Background:
- Epithelial cell-derived cytokines IL-25, IL-33, and TSLP initiate type 2 immune responses.
- Research over the past decade has focused on these initiating cytokines.
Purpose of the Study:
- To identify and characterize innate lymphoid cells involved in type 2 immunity.
- To understand the role of these cells in orchestrating immune responses.
Main Methods:
- Identification of a novel innate lymphoid cell subset.
- Analysis of cytokine production by this subset in response to IL-25 and IL-33.
Main Results:
- Discovery of group 2 or type 2 innate lymphoid cells (ILC2 cells).
- ILC2 cells produce canonical type 2 cytokines (IL-5, IL-9, IL-13).
- ILC2 cells are a critical in vivo source of type 2 cytokines.
Conclusions:
- ILC2 cells play a vital role in type 2 responses to helminths and allergens.
- Further research into ILC2 cell biology may reveal new therapeutic targets for asthma, allergies, and parasitic infections.
- Future research will explore ILC2 cell interactions with the adaptive immune system and their role in homeostasis.
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