Related Experiment Video

Updated: May 11, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Emerging drugs for the treatment of diabetic ulcers

Francesco Tecilazich1, Thanh L Dinh, Aristidis Veves

  • 1Harvard Medical School, Joslin-Beth Israel Deaconess Foot Center, and Microcirculation Lab, Beth Israel Deaconess Foot Center, Boston, MA, USA.

Expert Opinion on Emerging Drugs
|May 22, 2013
PubMed
Abstract

Insights

Diabetic foot ulcers are difficult to heal, leading to amputations. Research is exploring new topical therapies and understanding growth factor resistance to improve healing outcomes for diabetic wound care.

Area of Science:

  • Biomedical Science
  • Wound Healing Research
  • Diabetic Complications

Background:

  • Diabetic ulcers represent a significant clinical challenge, characterized by chronic non-healing and high amputation rates.
  • The biochemical environment of diabetic wounds is critically implicated in impaired healing processes.

Purpose of the Study:

  • To review the pathophysiology and conventional treatments for diabetic foot ulcers.
  • To present current research, including bench and translational studies.
  • To analyze drugs in development and clinical trials for diabetic wound healing.

Main Methods:

  • Literature review of pathophysiology and conventional treatments.
  • Analysis of current bench and translational research findings.
  • Examination of ongoing clinical trials and drug development pipelines.

Main Results:

  • Topical therapies are emerging to target abnormal growth factor expression and inflammatory cytokines.
  • Local wound sites show decreased growth factor expression.
  • Elevated systemic growth factor levels indicate potential growth factor resistance.

Conclusions:

  • Understanding chronic wound development has advanced therapeutic strategies.
  • Aberrant growth factor signaling and inflammation are key targets.
  • Growth factor resistance presents a challenge requiring further scientific investigation.

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