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Hydroxyamphetamine mydriasis in normal subjects.

S A Cremer1, H S Thompson, K B Digre

  • 1Department of Ophthalmology, University of Iowa, Iowa City.

American Journal of Ophthalmology
|July 15, 1990
PubMed
Summary
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Hydroxyamphetamine eyedrops cause pupil dilation to diagnose Horner's syndrome. Normal subjects show consistent pupil size changes between eyes, indicating low interocular variability for this diagnostic test.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Hydroxyamphetamine eyedrops are crucial for diagnosing Horner's syndrome by assessing sympathetic denervation.
  • Variability in drug response can complicate test interpretation in clinical settings.

Purpose of the Study:

  • To evaluate the interocular variability of hydroxyamphetamine's mydriatic effect in normal subjects.
  • To determine the extent of individual variation in response to hydroxyamphetamine eyedrops.

Main Methods:

  • Photographic documentation of pupil size changes in 26 normal subjects.
  • Administration of 1% hydroxyamphetamine hydrobromide eyedrops (Paredrine) to both eyes.
  • Measurement of pupil dilation and interocular asymmetry.

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Main Results:

  • Hydroxyamphetamine produced a mean pupil size increase of 1.96 mm (+/- 0.61 S.D.) across 52 eyes.
  • The mydriatic effect was symmetric between the eyes of individual subjects.
  • Mean interocular asymmetry was -0.087 mm (+/- 0.29 S.D.), demonstrating low variability.

Conclusions:

  • Hydroxyamphetamine eyedrops exhibit low interocular variability in normal individuals.
  • The consistent response suggests reliability for diagnosing Horner's syndrome, with inter-subject variability being the primary factor.