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Updated: May 11, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Update on zinc biology.

Noel W Solomons1

  • 1CESSIAM, Guatemala City, Guatemala. cessiam@guate.net.gt

Annals of Nutrition & Metabolism
|May 22, 2013
PubMed
Summary

Zinc is vital for human health, impacting growth and immunity. Emerging research explains how zinc deficiency stunts growth and how supplementation boosts resistance to infections.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Zinc is a critical nutrient with widespread roles in mammalian physiology and metabolism.
  • Understanding zinc's fundamental biological functions is crucial for public health and clinical practice.
  • Despite its importance, a complete basic science understanding of zinc's mechanisms is still developing.

Purpose of the Study:

  • To present recent advances in zinc homeostasis and transport.
  • To integrate these findings with genetic expression, intracellular signaling, immunity, and bone growth.
  • To provide mechanistic explanations for zinc's role in growth and infection resistance.

Main Methods:

  • Review of recent basic science research on zinc regulation and transport.

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Last Updated: May 11, 2026

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  • Integration of findings related to ionic zinc, transporters, metallothioneins, metalloenzymes, and zinc finger proteins.
  • Analysis of emerging research linking zinc to genetic expression and cellular signaling pathways.

    • Main Results:

    • Zinc homeostasis and transport are complex, involving multiple proteins and regulatory mechanisms.
    • Zinc plays a significant role in gene expression, intracellular signaling, and immune function.
    • Mechanistic links are emerging between zinc deficiency and delayed growth, and zinc supplementation and enhanced immunity.

    Conclusions:

    • Zinc's ubiquitous roles in human health are increasingly understood through basic science research.
    • Advances in understanding zinc transport and regulation offer insights into its impact on growth and immunity.
    • Further research is needed to fully elucidate the complex mechanisms underlying zinc's physiological effects.