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Published on: May 9, 2022
Refined brain tumor diagnostics and stratified therapies: the requirement for a multidisciplinary approach
Markus J Riemenschneider1, David N Louis, Michael Weller
1Department of Neuropathology, Regensburg University Hospital, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany. Markus.Riemenschneider@ukr.de
Abstract:
Individualized therapies are popular current concepts in oncology and first steps towards stratified medicine have now been taken in neurooncology through implementation of stratified therapeutic approaches. Knowledge about the molecular basis of brain tumors has expanded greatly in recent years and a few molecular alterations are studied routinely because of their clinical relevance. However, no single targeted agent has yet been fully approved for the treatment of glial brain tumors. In this review, we argue that multidisciplinary and integrated approaches are essential for translational research and the development of new treatments for patients with malignant gliomas, and we present a conceptual framework in which to place the components of such an interdisciplinary approach. We believe that this ambitious goal can be best realized through strong cooperation of brain tumor centers with local hospitals and physicians; such an approach enables close dialogue between expert subspecialty clinicians and local therapists to consider all aspects of this increasingly complex set of diseases.
Insights
Developing new treatments for malignant gliomas requires integrated, multidisciplinary approaches. Collaboration between brain tumor centers, hospitals, and physicians is key for advancing personalized oncology and stratified medicine.
Area of Science:
- Neuro-oncology
- Translational research
- Personalized medicine
Background:
- Molecular basis of brain tumors is increasingly understood.
- Stratified medicine approaches are emerging in neuro-oncology.
- No targeted agents are fully approved for glial brain tumors.
Purpose of the Study:
- To advocate for multidisciplinary and integrated approaches in translational research.
- To present a conceptual framework for interdisciplinary development of new treatments for malignant gliomas.
- To emphasize the need for collaboration between specialized centers and local healthcare providers.
Main Methods:
- Literature review and conceptual framework development.
- Analysis of current trends in neuro-oncology and personalized medicine.
- Discussion of essential components for interdisciplinary translational research.
Main Results:
- Multidisciplinary and integrated approaches are essential for advancing malignant glioma treatment.
- A conceptual framework is proposed to guide interdisciplinary efforts.
- Strong cooperation between brain tumor centers, hospitals, and physicians is crucial.
Conclusions:
- Effective development of new treatments for malignant gliomas necessitates an integrated, multidisciplinary strategy.
- Enhanced collaboration fosters dialogue and comprehensive patient care.
- This approach is vital for realizing the potential of personalized oncology in neuro-oncology.
