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Published on: February 6, 2021
Intraocular penetration of intravenous micafungin in inflamed human eyes
Kiyofumi Mochizuki1, Akira Sawada, Shinsuke Suemori
1Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan. mochi-gif@umin.ac.jp
Abstract:
Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases.
