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Published on: March 12, 2013
Association between KCNQ1 genetic variants and QT interval in a Chinese population
1Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai, China.
Genetic variants in KCNQ1 influence the QT interval in Chinese individuals without diabetes. This study found a specific KCNQ1 variant associated with prolonged QT intervals in healthy glucose regulation participants.
Area of Science:
- Cardiovascular genetics
- Diabetes research
- Molecular cardiology
Background:
- Electrocardiographic QT parameters are linked to Type 2 diabetes.
- KCNQ1 gene variants play a role in cardiac repolarization.
Purpose of the Study:
- To investigate the association between KCNQ1 gene variants and QT interval duration.
- To assess the impact of QT-related and diabetes-related KCNQ1 variants in a Chinese population.
Main Methods:
- Genotyping of four KCNQ1 single nucleotide polymorphisms (SNPs) in 2415 Type 2 diabetes patients and 1163 controls.
- Measurement of QT interval and calculation of heart rate-corrected QT interval (QTc) using Bazett's formula.
- Statistical analysis to determine associations between KCNQ1 SNPs and QTc interval.
Main Results:
- In individuals with normal glucose regulation, the minor allele T of rs12296050 was associated with a 3.46-ms QTc prolongation (P = 0.0109).
- No significant association was found between the studied KCNQ1 SNPs and QT interval in Type 2 diabetes patients.
- The findings suggest a genotype-dependent effect of KCNQ1 on cardiac repolarization.
Conclusions:
- KCNQ1 gene variants are associated with QT interval duration in a Chinese population with normal glucose regulation.
- The association between KCNQ1 and QT interval may differ between individuals with and without Type 2 diabetes.
- Further research is needed to elucidate the role of KCNQ1 in diabetes-related cardiac complications.
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