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Updated: May 11, 2026
10:04
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Immunologic microenvironment and personalized treatment in multiple myeloma
Marco Rossi1, Cirino Botta, Pierpaolo Correale
1Magna Graecia University and T. Campanella Cancer Center, Department of Experimental and Clinical Medicine, Medical Oncology Unit, Viale Europa, 88100 Catanzaro, Italy.
Expert Opinion on Biological Therapy
|May 23, 2013
Summary
Multiple myeloma (MM) causes immune suppression, increasing infection risks. Novel therapies, including bortezomib, show immunomodulatory effects, suggesting combined treatments to restore immune response against MM.
Area of Science:
- Immunology
- Oncology
- Hematology
Background:
- Multiple myeloma (MM) is characterized by generalized immune suppression.
- Malignant plasma cells (PCs) alter the bone marrow microenvironment, promoting their survival and proliferation.
- These changes lead to significant immune effector deregulation.
Purpose of the Study:
- To review the immunosuppressive effects of MM.
- To explore the immunomodulatory potential of novel anti-MM agents.
- To provide an overview of promising immunotherapeutic approaches for MM.
Main Methods:
- Literature review of immunosuppressive effects in MM.
- Analysis of immunomodulatory properties of novel anti-MM agents.
- Overview of current and emerging immunotherapeutic strategies.
Main Results:
- MM progressively impairs the immune system.
- Various approaches are being investigated to enhance anti-MM immune responses.
- Agents like bortezomib possess immunomodulatory properties.
Conclusions:
- Combined treatment modalities, including agents with immunomodulatory effects, are supported by current findings.
- Future directions include immunotherapy in early-stage MM or post-transplantation settings.
- Non-toxic immunotherapies aim to control or eliminate the neoplastic clone.
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