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Deficiency of methionine synthesis enzyme activity in ascites tumor cells
1Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Abstract:
Betaine-homocysteine- and S-adenosylmethionine-homocysteine-methyltransferases which catalyze synthesis of methionine from homocysteine are absent in tumor cells such as mouse Ehrlich ascites tumor cells and rat hepatoma AH-109A ascites cells.