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Updated: May 11, 2026

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
Published on: March 15, 2024
Peyronie's disease: a "triple oxygenant therapy"
Francesco Ciociola1, Giovanni Maria Colpi
1U.O.C. Urologia 2 - Andrologia e Riproduzione Assistita, Azienda Ospedaliera San Paolo - Polo Universitario, Milano, Italy. ciociolafrancesco@libero.it
Objectives:
To evaluate the effects of upregulators of nitric oxide in one patient with Peyronie’s disease, after non significant improvement following intracavernosal verapamil.
Methods:
A 20-years-old Caucasian male presented with penile induration in flaccid state, persistent during erection and associated with mild pain at third middle of penis. After treatment with intracavernosal verapamil for 4 months with relief of penile discomfort, followed by counseling on the use of penile extender for at least 6 hours per day, he was prescribed pentoxifylline associated with tadalafil plus levo-arginine, propionil-carnitine and Vitamin B3.
Results:
After almost 2 years, the septal thickness was reduced at ultrasound evaluation after this “triple oxygenant therapy”.
Conclusion:
NO-iNOS biology in Peyronie patients is the very protagonist in modulating penile fibrosis through up-regulation of NO-cGMP pathway that influences penile health by preventing and reversing fibrosis in the tunical albuginea.
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