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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: May 11, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Inflammatory bowel disease epidemiology.

Johan Burisch1, Pia Munkholm

  • 1Medical Section, Digestive Disease Centre, Herlev University Hospital, Herlev, Copenhagen, Denmark.

Current Opinion in Gastroenterology
|May 23, 2013
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) is rising globally. New treatments may alter IBD

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Area of Science:

  • Gastroenterology
  • Epidemiology
  • Immunology

Background:

  • Global incidence of inflammatory bowel disease (IBD) is increasing.
  • Reasons for the rising IBD rates are currently unknown.
  • New therapeutic strategies are emerging for IBD management.

Purpose of the Study:

  • To review current findings on the epidemiology of inflammatory bowel disease.
  • To summarize recent trends in IBD incidence and outcomes.
  • To discuss the impact of new therapies on the natural history of IBD.

Main Methods:

  • Literature review of recent epidemiological studies on IBD.
  • Analysis of incidence and prevalence data from various global regions.
  • Evaluation of treatment outcomes, including colectomy rates and mortality.

Main Results:

  • IBD incidence is higher in Western Europe than Eastern Europe, with the Faroe Islands reporting the highest rates globally.
  • Early use of immunosuppressants and biologics may reduce colectomy rates in ulcerative colitis, but impact on Crohn's disease is unclear.
  • Mortality in Crohn's disease remains unchanged; however, specialized care and achieving mucosal healing may improve future outcomes. Colorectal cancer risk in Crohn's disease is similar to ulcerative colitis, with increased adenocarcinoma risk in small bowel Crohn's disease.

Conclusions:

  • The natural course of IBD may be shifting towards a 'treat to target' approach focused on mucosal healing.
  • Population-based studies of unselected IBD cohorts are essential for future research.
  • Further investigation is needed to understand the long-term effects of new therapies on IBD progression and outcomes.