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Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging
Yu-Mei Zhou1, Hai-Bao Wang, Ming Gong
1Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, 230026, PR China.
Abstract:
Nearly monodispersed yolk-type Au@Fe3O4@C nanospheres with hollow cores of 50 nm in diameter were prepared through coating Au@SiO2 nanoparticles with Fe3O4@C double layers, followed by dissolving SiO2. The cytotoxicity of the nanospheres was evaluated by MTT assay, demonstrating a high biocompatibility. The yolk-type nanospheres show a high DOX loading content of 1237 mg g(-1). The coexistence of Fe3O4 and Au also makes the nanospheres as dual probes for MR imaging with a specific relaxivity (r2*) of 384.38 mM(-1) s(-1) and optical fluorescence imaging using a near-infrared (NIR) excitation.
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