Related Experiment Video
Updated: May 11, 2026
An “All-laser” Endothelial Transplant
Published on: July 6, 2015
[Anti(lymph)angiogenic preconditioning prior to keratoplasty]
C Cursiefen1, B Regenfuss, D Hos
1Universitätsaugenklinik, Universität zu Köln, Kerpener Strasse 62, Köln. claus.cursiefen@uk-koeln.de
Purpose:
The aim of this study is to describe novel therapeutic concepts to promote graft survival in high-risk keratoplasty by targeting (lymph)angiogenesis in the transplant context.
Methods:
A PubMed literature search and our own clinical and experimental data are evaluated.
Results:
There are three options for anti(lymph)angiogenic preconditioning: a) primary prevention of neovascularisation during the disease process, b) secondary prevention by regressing established blood vessels prior to transplantation and (c) tertiary prevention through inhibition of post-keratoplasty neovascularisation.
Conclusion:
Modern topical anti(lymph)angiogenic therapies seem to be able to reduce the risk of graft rejection especially in high-risk keratoplasty.
