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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
Published on: November 17, 2015
Development and evaluation of glyceryl behenate based solid lipid nanoparticles (SLNs) using hot
Jeetendra Singh Negi1, Pronobesh Chattopadhyay, Ashok Kumar Sharma
1Department of Pharmaceutical Sciences, S Bhagwan Singh PG Institute of Bio-medical Sciences and Research, Balawala, Dehradun, 248161, Uttarakhand, India, rx.jnegi@gmail.com.
Archives of Pharmacal Research
|May 23, 2013
Summary
Solid lipid nanoparticles (SLNs) significantly enhanced the oral bioavailability of lopinavir by 3.56-fold. This formulation strategy improved drug delivery for poorly soluble compounds.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Drug Delivery
Background:
- Lopinavir is a poorly water-soluble drug with limited oral bioavailability.
- Solid lipid nanoparticles (SLNs) offer a promising approach to enhance the delivery of such drugs.
Purpose of the Study:
- To improve the oral bioavailability of lopinavir using glyceryl behenate-based SLNs.
- To investigate the efficacy of the hot self-nanoemulsification (SNE) technique for SLN preparation.
Main Methods:
- Lopinavir-loaded SLNs were prepared using the hot SNE technique with glyceryl behenate, Poloxamer 407, and polyethylene glycol 4000.
- Characterization included particle size, zeta potential, entrapment efficiency, and morphological analysis (TEM, AFM).
- Solid-state properties were assessed using differential scanning calorimetry (DSC) and X-ray diffraction (XRD).
Main Results:
- Optimized SLNs exhibited a particle size of 214.5 ± 4.07 nm, entrapment efficiency of 81.6 ± 2.3%, and zeta potential of -12.7 ± 0.87 mV.
- Morphological studies confirmed the formation of SLNs.
- Lopinavir-loaded SLNs demonstrated a 3.56-fold higher oral bioavailability compared to the bulk drug, attributed to increased lymphatic transport.
Conclusions:
- The hot SNE technique is effective for preparing glyceryl behenate-based SLNs.
- SLNs significantly enhance the oral bioavailability of lopinavir, offering a viable strategy for improving drug delivery.
