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Updated: May 11, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
Published on: October 1, 2017
Long distance charge transport through DNA: quantification and extension of the hopping model
1Department of Chemistry University of Basel St Johanns Ring 19, 4056 Basel, Switzerland. bernd.giese@unibas.ch
Abstract:
Long distance charge transport through DNA occurs by a hopping mechanism. If the positive charge is injected into a guanine base, all guanines act as charge carriers. Because of the strong influence that the distance has on the charge-transfer step, DNA strands with long adenine:thymine sequences also involve adenine as charge carriers. A prerequsite for this mechanism is that the electron transfer to an adjacent adenine base is faster than the H2 O trapping reaction of the guanine radical cation. We have developed a model that can explain and qualitatively predict the product yields.
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