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Fluorescence 'turn-on' sensor for F- derived from vitamin B6 cofactor
Darshna Sharma1, Suban K Sahoo, Soma Chaudhary
1Department of Applied Chemistry, SV National Institute of Technology (SVNIT), Surat, Gujrat, India.
The Analyst
|May 23, 2013
Summary
A new vitamin B6 Schiff base analog (L) acts as a selective sensor for fluoride and acetate ions, showing a visible color change and a
Area of Science:
- Biochemistry
- Analytical Chemistry
- Supramolecular Chemistry
Background:
- Vitamin B6 derivatives are crucial in biological systems.
- Schiff bases are versatile ligands with applications in sensing.
- Anion sensing remains a significant challenge in analytical chemistry.
Purpose of the Study:
- To synthesize a novel vitamin B6 Schiff base analog (L).
- To investigate the sensing capabilities of receptor L for anions.
- To develop a selective and sensitive method for fluoride detection.
Main Methods:
- Synthesis of a vitamin B6 Schiff base analog (L) from pyridoxal and 2-aminophenol.
- Spectrophotometric and fluorometric analysis of receptor L with various anions.
- Investigation of host-guest complex formation and stoichiometry.
Main Results:
- Receptor L exhibited a naked-eye detectable color change from yellow to red in the presence of fluoride and acetate.
- The color change is attributed to the formation of 1:1 host-guest complexes via hydrogen bonding.
- Receptor L demonstrated a fluoride-selective 'turn-on' fluorescent response with a low detection limit (7.39 × 10⁻⁸ M).
Conclusions:
- The synthesized vitamin B6 Schiff base analog (L) is an effective chemosensor for fluoride and acetate.
- Receptor L offers a simple, visual, and sensitive method for fluoride detection.
- This study highlights the potential of vitamin B6 derivatives in developing advanced anion sensors.
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