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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: May 11, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Muscle tissue changes with aging.

Ana Fátima Pereira1, António José Silva, Aldo Matos Costa

  • 1Departamento de Ciências do Desporto, Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal.

Acta Medica Portuguesa
|May 24, 2013
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly influence muscle mass and strength, impacting sarcopenia risk in the elderly. Understanding these genetic links, alongside exercise and nutrition, is key to healthy aging and mitigating muscle loss.

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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

  • Gerontology and Exercise Science
  • Molecular Genetics and Aging Research

Background:

  • Sarcopenia, a decline in muscle mass and function with aging, presents a significant health concern.
  • Heritability estimates for muscle strength (30-85%) and mass (45-90%) highlight a strong genetic component in elderly populations.
  • Building muscle mass in early adulthood is crucial for reducing sarcopenia risk and promoting healthy aging.

Purpose of the Study:

  • To review genetic polymorphisms associated with muscle phenotypes in older adults.
  • To explore the interplay between genetic factors, aging, and musculoskeletal response to exercise.
  • To examine the roles of nutrition and exercise in mitigating age-related muscle decline.

Main Methods:

  • Systematic review of existing literature on genetic polymorphisms and sarcopenia-related muscle phenotypes.
  • Analysis of studies focusing on elderly populations and their muscle characteristics.
  • Inclusion of research on nutritional and exercise interventions relevant to aging muscle.

Main Results:

  • Evidence suggests associations between specific genetic polymorphisms and muscle mass/strength in older individuals.
  • Inconsistencies across studies indicate a need for further research with larger sample sizes and diverse physical activity levels.
  • Genetic factors, exercise, and nutrition collectively influence muscle physiology and sarcopenia risk.

Conclusions:

  • Identifying genetic factors influencing muscle aging is vital for personalized interventions.
  • Further research into genetic etiology and metabolic pathways will enhance understanding of muscle physiology.
  • Improved recognition of high-risk individuals can lead to more effective management of sarcopenia.