Controlling mammalian gene expression by allosteric hepatitis delta virus ribozymes

Yoko Nomura1, Linlin Zhou, Anh Miu

  • 1Department of Biomedical Engineering, University of California, Davis , 451 Health Sciences Drive, Davis, California 95616, United States.

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Ribozymes can be...
Ribozymes02:47

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can be...
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