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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
TiPs: a database of therapeutic targets in pathogens and associated tools
Rosalba Lepore1, Anna Tramontano, Allegra Via
1Department of Physics, Sapienza University, 00185 Rome, Italy.
Motivation:
The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes.
Availability And Implementation:
The TiPs database is freely available at http://biocomputing.it/tips.
Contact:
anna.tramontano@uniroma1.it or allegra.via@uniroma1.it.
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