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Updated: May 11, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Quantitative dynamics of adipose cells.

Junghyo Jo1, Zeina Shreif, Vipul Periwal

  • 1Laboratory of Biological Modeling; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Bethesda, MD USA.

Adipocyte
|May 24, 2013
PubMed
Summary

Adipose cell size dynamics are key to lipid metabolism and energy balance. Mathematical modeling of adipose cell size distributions reveals growth limitations in larger cells, offering insights into obesity.

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Area of Science:

  • Cell Biology
  • Metabolic Science
  • Computational Biology

Background:

  • Adipose cells dynamically change size for lipid storage and release, essential for energy homeostasis.
  • Regulation of adipose cell size during energy excess/scarcity remains unclear.
  • Direct real-time monitoring of individual adipose cell processes is technically challenging.

Purpose of the Study:

  • To investigate adipose cell size dynamics and lipid metabolism regulation.
  • To explore the utility of computational approaches for analyzing adipose cell populations.
  • To understand the mechanisms underlying adipose cell turnover and their relation to metabolic state.

Main Methods:

  • Utilized computational approaches to analyze adipose cell-size probability distributions.
Keywords:
adipogenesisapoptosiscell size distributionlipid dropletlipogenesislipolysismathematical modelingsize-dependent growthturnover

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Last Updated: May 11, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue
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Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue

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  • Applied quantitative modeling to integrate adipose cell dynamics.
  • Measured adipose cell size distributions and physiological metabolic state.

    • Main Results:

    • Adipose cell growth/shrinkage under varying energy balance is proportional to cell surface area for cells > 50 μm diameter.
    • This surface area dependency limits lipid absorption/release efficiency in larger adipose cells.
    • Quantitative modeling elucidated mechanisms of cell turnover in normal and drug-treated states.

    Conclusions:

    • Mathematical modeling of adipose cell size distributions provides insights into lipid metabolism regulation.
    • Adipose cell size dynamics, particularly in larger cells, impact energy homeostasis.
    • Integrating computational modeling with experimental data can unravel complex interactions in metabolic syndromes like obesity.