Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Nondestructive Raman Spectral Method for Temporal Tracking of Articular Cartilage Maturation.

Tissue engineering. Part A·2026

Same author

Isolation, purification and characterization of lipocartilage in mice.

Nature protocols·2026

Same author

Minipig costal and knee cartilage structure-function relationships and their use as cell sources for tissue-engineered analogous cellular products for cartilage repair.

Acta biomaterialia·2025

Same author

Integrated experimental and <i>In silico</i> evaluation of the antioxidant, antibacterial, antiviral, and antiproliferative activities of <i>Boswellia neglecta</i> S. Moore stem extract and its bioactive constituents.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2025

Same author

Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.

The journal of pain·2025

Same author

Influence of L-arginine on hydroxyapatite-based ovine bone graft - An <i>in vitro</i> evaluation of surface characteristics and cell viability.

Dental research journal·2025

Same journal

Physics-Informed Machine Learning in Biomedical Science and Engineering.

Annual review of biomedical engineering·2026

Same journal

Advancements and Challenges in Computer-Assisted Medical Interventions for Image-Guided Prostate Cancer Treatments.

Annual review of biomedical engineering·2026

Same journal

Recent Advances in mRNA Therapeutic Cancer Vaccines.

Annual review of biomedical engineering·2026

Same journal

Artificial Intelligence-Based Analysis of Laparoscopic Imaging for Intraoperative Surgical Decision Support.

Annual review of biomedical engineering·2026

Same journal

Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.

Annual review of biomedical engineering·2026

Same journal

Digital Twins for Biofluids.

Annual review of biomedical engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 11, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Self-organization and the self-assembling process in tissue engineering.

Kyriacos A Athanasiou¹, Rajalakshmanan Eswaramoorthy, Pasha Hadidi

¹Department of Biomedical Engineering, University of California, Davis, CA 95616, USA. athanasiou@ucdavis.edu

Annual Review of Biomedical Engineering

|May 25, 2013

Summary

This summary is machine-generated.

Scaffoldless tissue engineering techniques harness self-organization and self-assembly to create tissues. These methods mimic in vivo processes, yielding tissues with native-like structure and function for clinical applications.

More Related Videos

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Related Experiment Videos

Last Updated: May 11, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Area of Science:

Regenerative Medicine
Tissue Engineering
Biotechnology

Background:

The field of tissue engineering is evolving with scaffoldless techniques.
These methods focus on self-organizing and self-assembling tissues.
This approach contrasts with traditional scaffold-based methods.

Purpose of the Study:

To review the emerging field of scaffoldless tissue engineering.
To define self-organization and self-assembly in this context.
To highlight clinical applications and research models.

Main Methods:

Review of current literature on scaffoldless tissue engineering.
Analysis of self-organization and self-assembly processes.
Examination of in vivo biological process parallels.

Main Results:

Self-organizing and self-assembling tissues recapitulate native morphological structure.
Engineered tissues exhibit functional properties approaching native tissue values.
Some of these tissues are already in clinical trials.

Conclusions:

Self-organization and self-assembly offer promising solutions in tissue engineering.
These techniques hold potential for addressing complex tissue regeneration challenges.
The review provides a cohesive summary of this rapidly advancing research area.