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Cellular Injury II: Classification01:21

Cellular Injury II: Classification

Cellular injury is any process that disrupts a cell’s ability to maintain homeostasis, leading to structural or functional changes. It is broadly classified based on etiology (cause) and mechanism of damage.Classification by EtiologyCellular injury may result from several causes. Hypoxic injury happens due to reduced oxygen delivery, most commonly from inadequate blood supply, such as arterial obstruction; for example, coronary artery thrombosis can cause myocardial infarction. Chemical injury...
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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Cellular Injury IV: Necrosis01:16

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Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Cellular Injury I: Introduction01:00

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Cellular injury occurs when a cell cannot maintain homeostasis or adapt to stressors such as hypoxia, toxins, or trauma. Depending on severity and duration, injury may be reversible, allowing recovery, or irreversible, leading to cell death.General Mechanisms of Cell InjuryAlthough causes vary, most cellular injuries arise from a few key mechanisms that disrupt essential functions and often amplify one another. Cell survival depends on the extent and balance of these disturbances.ATP depletion...

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A classification of the mechanisms producing pathological tissue changes.

John O Grippo1, Daniel S Oh

  • 1Biomedical Engineering, Western New England University, Springfield, 01119, USA. meadownet@aol.com

Journal of Medical Engineering & Technology
|May 25, 2013
PubMed
Summary

This study classifies pathological mechanisms and defines biocorrosion, referring to chemical, biochemical, and electrochemical changes in tissues. It clarifies biocorrosion for biomedical engineering, medicine, dentistry, and veterinary medicine.

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Area of Science:

  • Biomedical Engineering
  • Pathology
  • Materials Science

Background:

  • Precise definitions are crucial in emerging biomedical fields.
  • Existing terminology for tissue degradation lacks specificity.
  • Biocorrosion requires a clear, encompassing definition.

Purpose of the Study:

  • To classify mechanisms causing pathological changes in tissues and fluids.
  • To define and clarify the term biocorrosion for interdisciplinary use.
  • To differentiate biocorrosion from traditional corrosion concepts.

Main Methods:

  • Literature review and conceptual analysis.
  • Classification of pathological mechanisms (stress, friction, biocorrosion).
  • Definition and scope of biocorrosion established.

Main Results:

  • A classification of pathological mechanisms affecting tissues is presented.
  • Biocorrosion is defined as chemical, biochemical, and electrochemical changes in living tissues and fluids.
  • Various agents inducing biocorrosion are identified.

Conclusions:

  • A precise, encompassing definition of biocorrosion is essential for biomedical engineering and related sciences.
  • Distinguishing biocorrosion from general corrosion is necessary.
  • This work provides a foundation for standardized terminology.