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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

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Related Experiment Video

Updated: May 11, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

Flavonoids on allergy.

Margarida Castell, Francisco J Pérez-Cano, Mar Abril-Gil

  • 1Faculty of Pharmacy, Department of Physiology, Av Joan XXIII s/n, Barcelona E-08028, Spain. margaridacastell@ub.edu.

Current Pharmaceutical Design
|May 25, 2013
PubMed
Summary
This summary is machine-generated.

Flavonoids show potential in preventing allergies by reducing immunoglobulin E (IgE) and mast cell degranulation. Further clinical trials are needed to confirm their therapeutic role in allergic conditions.

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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Published on: June 4, 2017

Area of Science:

  • Phytochemistry
  • Immunology
  • Pharmacology

Background:

  • Flavonoids are diverse plant compounds with potential anti-allergic properties.
  • Preclinical studies suggest flavonoids inhibit immunoglobulin E (IgE) synthesis and mast cell degranulation.

Purpose of the Study:

  • To review the role of flavonoids in preventing and treating allergic diseases.
  • To explore the cellular mechanisms underlying flavonoid activity in allergies.

Main Methods:

  • Review of preclinical (rodent models) and clinical studies on flavonoids and allergies.
  • Analysis of cellular mechanisms including receptor expression, calcium influx, and signaling pathways.

Main Results:

  • Animal models show flavonoids reduce airway hyperresponsiveness, inflammation, and cell infiltration in allergic asthma.
  • Clinical trials indicate promising results for flavonoids in allergic asthma and rhinitis.
  • Flavonoids modulate IgE receptor expression, calcium influx, and signaling pathways, reducing mediator release.

Conclusions:

  • Certain flavonoids may serve as alternative or complementary therapies for allergies.
  • More extensive clinical trials are necessary to validate the therapeutic efficacy of flavonoids.