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Updated: May 11, 2026
06:38
High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
Published on: February 7, 2019
Receptor conformational change induces fluoride binding despite competitive water binding
Laurent Trembleau1, Tim A D Smith, Mostafa H Abdelrahman
1School of Natural and Computing Sciences, University of Aberdeen, Aberdeen AB24 3UE, UK. l.trembleau@abdn.ac.uk
Chemical Communications (Cambridge, England)
|May 25, 2013
Summary
A new boron-based receptor selectively binds fluoride in acidic water. This breakthrough offers a promising method for fluoride detection and removal, overcoming previous challenges in anion binding.
Area of Science:
- Supramolecular Chemistry
- Anion Recognition
- Materials Science
Background:
- Fluoride anion binding in aqueous solutions is difficult due to its high hydration energy.
- Developing artificial receptors for selective anion recognition remains a significant challenge in chemistry.
Purpose of the Study:
- To synthesize and characterize a novel cationic boron-based tripodal receptor for fluoride anion binding.
- To investigate the selectivity and affinity of the receptor for fluoride in aqueous media.
Main Methods:
- Synthesis of a tripodal boron-based receptor with ammonium-containing arms.
- Nuclear Magnetic Resonance (NMR) spectroscopy to study receptor-anion interactions.
- Evaluation of binding affinity and selectivity in acidic aqueous conditions.
Main Results:
- Successful preparation of the novel cationic boron-based tripodal receptor.
- NMR studies confirmed selective binding of the fluoride anion.
- The receptor demonstrated high affinity for fluoride in acidic water.
Conclusions:
- The developed boron-based receptor effectively binds fluoride anions in water.
- This receptor shows potential for applications in fluoride detection or removal.
- The study highlights a new strategy for designing artificial receptors for challenging anions.
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