Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Learning Disabilities01:25

Learning Disabilities

Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental enrichment as a tractable approach to promoting psychiatric resilience across the lifespan.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.

Nature communications·2026
Same author

A Scalable fMRI Estimate of Basal Ganglia Brain Tissue Iron for Use in Developmental and Translational Neuroscience.

bioRxiv : the preprint server for biology·2026
Same author

Trajectories of Response Inhibition Development in Adolescence.

bioRxiv : the preprint server for biology·2026
Same author

Lifespan changes in functional brain activation during conflict-processing: reconciling development and aging.

Science bulletin·2026
Same author

Basal Ganglia Dopamine Availability and Immune Activation Interact and Relate to Anhedonia Severity among Youth with Depression.

Research square·2026

Related Experiment Video

Updated: May 11, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

Saccade adaptation abnormalities implicate dysfunction of cerebellar-dependent learning mechanisms in Autism Spectrum

Matthew W Mosconi1, Beatriz Luna, Margaret Kay-Stacey

  • 1Departments of Psychiatry and Pediatrics, University of Texas Southwestern, Dallas, Texas, United States of America. Matt.Mosconi@UTSouthwestern.edu

Plos One
|May 25, 2013
PubMed
Summary

Individuals with autism spectrum disorder (ASD) show impaired saccadic eye movement adaptation, indicating reduced neural plasticity in the cerebellar vermis. This affects motor control and fine-tuning.

More Related Videos

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Eye Tracking Young Children with Autism
09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

Related Experiment Videos

Last Updated: May 11, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Eye Tracking Young Children with Autism
09:03

Eye Tracking Young Children with Autism

Published on: March 27, 2012

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Autism Research

Background:

  • The cerebellar vermis is implicated in autism spectrum disorders (ASD).
  • This region is crucial for accurate saccadic eye movements and error correction.
  • Saccade adaptation paradigms have not been previously applied to ASD research.

Purpose of the Study:

  • To investigate saccade adaptation in individuals with ASD using an intrasaccadic target displacement task.
  • To compare adaptation rates and saccade amplitude variability between individuals with ASD and healthy controls.
  • To explore the relationship between motor adaptation deficits and manual motor control in ASD.

Main Methods:

  • Fifty-six individuals with ASD and 53 healthy controls performed a saccade adaptation task.
  • The study examined adaptation rate and saccade amplitude variability over 180 trials.
  • Neuropsychological tests assessed manual motor control.

Main Results:

  • Individuals with ASD exhibited slower adaptation rates and greater saccade amplitude variability compared to controls.
  • A significant portion of individuals with ASD (30%) failed to adapt, versus 6% of controls.
  • Impaired adaptation and increased variability correlated with poorer manual motor control.

Conclusions:

  • Reduced neural plasticity in the oculomotor vermis contributes to motor control deficits in ASD.
  • Impaired saccade adaptation provides functional evidence of cerebellar abnormalities in ASD.
  • These findings align with existing anatomical and cellular research on ASD.