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High conversion self-curing sealer based on a novel injectable polyurethane system for root canal filling.
1Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu 610064, PR China.
Summary
This study introduces a new polyurethane root canal filling material that achieves high monomer-polymer conversion, reducing cytotoxicity. This self-curing system demonstrates excellent cell compatibility and superior physicochemical properties compared to commercial sealers.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Endodontics
Background:
- Low monomer-polymer conversion in resin-based dental materials causes cytotoxicity.
- Existing root canal sealers may exhibit limitations in conversion rates and biocompatibility.
Purpose of the Study:
- To develop and evaluate a novel self-curing injectable polyurethane (PU) root canal filling system.
- To assess the conversion efficiency, cytotoxicity, and physicochemical properties of the new PU sealer.
Main Methods:
- Fourier Transform Infrared (FTIR) spectroscopy was used to trace NCO group conversion.
- Cell culture studies with L929 murine fibroblasts evaluated cell attachment and proliferation.
- Physicochemical properties were tested according to ISO 6876:2001 standards and compared with commercial sealers (AH Plus, Apexit Plus).
Main Results:
- The PU sealer achieved over 90% NCO group conversion within 4 hours, indicating a highly efficient curing process.
- The material demonstrated favorable biocompatibility, supporting L929 fibroblast attachment and proliferation.
- The PU sealer met clinical requirements and exhibited superior physicochemical properties compared to AH Plus and Apexit Plus.
Conclusions:
- The developed self-curing PU root canal sealer offers high conversion and reduced cytotoxicity.
- Its favorable biological and physicochemical properties suggest significant potential for endodontic applications.
- Further biological evaluation is recommended before widespread clinical adoption.
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