Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A clinically integrated, frameless human Neuropixels workflow.

medRxiv : the preprint server for health sciences·2026
Same author

Establishment of High Channel-Count Packaging in Active Implantable Medical Devices for Neuroprosthesis.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

Investigating the Biomechanics to Mimic Blinking using an Electromagnetic Actuator.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Prototype Hardware for Closed-loop Stimulation of the Retina.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Capacitive Silicone-Textile Strain Sensor for Soft Biomedical Applications.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Development of a Low-Cost Electrospinner for Fabrication of Polyacrylonitrile Fibers as a Precursor to Flexible Carbon Neural Electrodes.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

Related Experiment Video

Updated: May 11, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Integrated electrode and high density feedthrough system for chip-scale implantable devices.

Rylie A Green1, Thomas Guenther, Christoph Jeschke

  • 1Graduate School of Biomedical Engineering, Sydney, NSW 2052, Australia. r.green@unsw.edu.au

Biomaterials
|May 28, 2013
PubMed
Summary

New high-density feedthroughs integrate over 1100 stimulating sites on implantable devices. These hermetic, layered alumina and platinum microelectrodes demonstrate electrical stability and biocompatibility for neural stimulation applications.

More Related Videos

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

Related Experiment Videos

Last Updated: May 11, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays
08:54

Chronic Implantation of Multiple Flexible Polymer Electrode Arrays

Published on: October 4, 2019

An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Developing high-density electrode arrays for neural interfaces is crucial for advanced neuroprosthetics.
  • Existing technologies face challenges in integration, hermeticity, and long-term stability.
  • Need for biocompatible materials with high charge injection capacity is critical for effective neural stimulation.

Purpose of the Study:

  • To develop and characterize novel high-density feedthroughs for implantable electronic devices.
  • To evaluate the electrical stability and biological properties of the developed microelectrode arrays.
  • To assess the potential of these feedthroughs for supporting neural cell function.

Main Methods:

  • Fabrication of layered alumina sheets with integrated platinum (Pt) microelectrodes.
  • Characterization of hermetic properties and layer count flexibility.
  • Assessment of electrode surface morphology and charge injection capacity.
  • Electrical stability testing with over 1.8 billion stimulation pulses.
  • Biological evaluation using cell growth inhibition assays and neural cell culture.

Main Results:

  • Successfully developed high-density feedthroughs with up to 1141 stimulating sites on a single package.
  • Layered alumina technology offers hermetic sealing and scalability for complex routing.
  • Platinum microelectrodes exhibit porous morphology, leading to high charge injection capacity.
  • Electrodes maintained electrical stability after extensive stimulation.
  • Ceramic-Pt constructs showed no cell growth inhibition and supported neural cell survival and differentiation.

Conclusions:

  • The developed high-density feedthroughs are suitable for integration into implantable neural stimulation devices.
  • The technology offers a robust, hermetic, and scalable solution for advanced neural interfaces.
  • The microelectrodes possess excellent electrical and biological properties for long-term neural interfacing.