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Membrane anchoring γ-secretase modulators with terpene-derived moieties

Eva Christine Naumann1, Stefan Göring, Isabella Ogorek

  • 1Clemens Schöpf-Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

Bioorganic & Medicinal Chemistry Letters
|May 28, 2013
PubMed
Summary

New small molecules targeting gamma-secretase (γ-secretase) show promise for Alzheimer's disease treatment. These compounds decrease harmful Aβ42 and increase beneficial Aβ38 production by modulating enzyme activity.

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