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ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol

Anna Fernandez1, Núria Matias, Raquel Fucho

  • 1Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain; Liver Unit-Hospital Clinic-IDIBAPS, and CIBEREHD, Barcelona, Spain.

Journal of Hepatology
|May 28, 2013
PubMed
Abstract

Keywords:
ALDASMaseAlcohol induced liver diseaseBHMTCBSCeramideDGAT2ERER stressFASHcyHomocysteineMAT1AMCDMSMitochondrial GSHMitochondrial cholesterolNSMasePHSMSREBPSgms2Smgs1StARD1TUDCAUPRacid sphingomyelinasealcohol induced liver diseasebetaine homocysteine methyl transferasecystathionine-β-synthasediacylglycerol transferase 2endoplasmic reticulumfatty acid synthasehomocysteinemCholmGSHmethionine adenosyl transferase 1Amethionine and choline deficientmethionine synthasemitochondrial GSHmitochondrial cholesterolneutral sphingomyelinasepartial hepatectomysphingomyelinsphingomyelin synthase1sphingomyelin synthase2steroidogenic acute regulatory domain proteinsterol regulatory element binding proteintauroursodeoxycholic acidunfolded protein response

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