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Portable method of measuring gaseous acetone concentrations.

Adam D Worrall¹, Jonathan A Bernstein, Anastasios P Angelopoulos

¹Chemical Engineering Program, University of Cincinnati, Cincinnati, OH 45221, USA.

|May 28, 2013

Summary

A novel breath analysis method uses a polymer membrane to detect acetone, offering a simple, non-invasive tool for monitoring diabetes. This portable device provides real-time insights into diabetic control without complex equipment.

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Area of Science:

Analytical Chemistry
Medical Diagnostics
Polymer Science

Background:

Acetone in human breath is a key indicator for monitoring diabetes mellitus control.
Current breath acetone measurement methods often require complex instrumentation and pre-concentration, limiting point-of-care applications.
Non-invasive, portable diagnostic tools are needed for real-time patient monitoring.

Purpose of the Study:

To develop a novel, portable optical sensing device for the non-invasive measurement of acetone in human breath.
To enable real-time analysis of acetone concentrations for improved diabetes management.

Main Methods:

Immobilization of resorcinol reagent within a perfluorosulfonic acid polymer membrane.
Utilizing a controlled organic synthesis reaction between immobilized resorcinol and acetone in a dry carrier gas.
Detection of a visible spectrum color change in the reaction product (flavan) for quantitative acetone measurement.

Main Results:

The developed method allows for the detection of acetone concentrations below parts per million (ppm).
The immobilized reagent demonstrates high selectivity for acetone.
The colorimetric reaction provides a measurable visible spectrum change correlated with acetone levels.

Conclusions:

This approach enables the creation of a portable optical sensing device for real-time, non-invasive acetone analysis.
The technology offers a promising, simplified method for monitoring diabetic conditions at the point-of-care.
Further development could lead to widespread use in diabetes management and diagnostics.