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Updated: May 11, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Codeine-associated pediatric deaths despite using recommended dosing guidelines: three case reports

Stefan J Friedrichsdorf1, Andrea Postier Nugent, A Quinn Strobl

  • 1Department of Pain Medicine, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA.

Journal of Opioid Management
|May 28, 2013
PubMed

Insights

Codeine toxicity caused three child deaths despite appropriate dosing. Genetic factors and obesity increase risks, suggesting codeine should not be prescribed to children due to its dangers.

Area of Science:

  • Pharmacology
  • Pediatric Toxicology
  • Genetics

Background:

  • Codeine is a common analgesic.
  • Its efficacy and safety depend on CYP2D6 metabolism.
  • Genetic variations in CYP2D6 can lead to toxicity or inefficacy.

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