Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patient-centered Care01:13

Patient-centered Care

3.1K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

266
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

314
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
314
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

236
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
236
Data Reporting and Recording01:24

Data Reporting and Recording

5.5K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.5K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

305
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
305

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bringing leaders together to support the development of children's palliative care across the Asia Pacific region-an interdisciplinary workshop.

Ecancermedicalscience·2026
Same author

Milestones and Horizons: Highlights from the 4th International Children's Palliative Care Network Conference in Manila, Philippines.

Ecancermedicalscience·2026
Same author

Quality domains in home-based pediatric hospice and palliative care: adolescent and young adult perspectives.

BMC palliative care·2026
Same author

Physician Perceptions Toward Palliative Care Integration in Childhood Cancer Care in Asia Pacific.

JCO global oncology·2026
Same author

Addressing neonatal intensive care unit clinicians' distress via interprofessional meetings.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

"Not designed for families like ours"-barriers to care among families of young children with spina bifida.

Disability and rehabilitation·2026

Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K

Integrating Electronic Patient-Reported Outcomes and Palliative Care in Pediatric Advanced Cancer: The PediQUEST

Veronica Dussel1, Liliana Orellana2, Maria L Requena3

  • 1Pediatric Palliative Care Research and Innovation Lab, MassGeneral for Children, Boston, MA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|February 4, 2026
PubMed
Summary

Combining electronic patient-reported outcomes with pediatric palliative care improved health-related quality of life in children with advanced cancer. Further implementation strategies are needed to maximize benefits.

More Related Videos

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.6K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.8K

Related Experiment Videos

Last Updated: Feb 6, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.2K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.6K
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.8K

Area of Science:

  • Pediatric Oncology
  • Palliative Care
  • Health-Related Quality of Life (HRQOL)

Background:

  • Advanced cancer significantly impacts children's HRQOL.
  • Integrating technology and specialized care can potentially improve outcomes.

Purpose of the Study:

  • To assess if combining electronic patient-reported outcome (ePRO) feedback with specialized pediatric palliative care (SPPC) consultation improves HRQOL in children with advanced cancer.
  • To evaluate the PediQUEST Response to the Pediatric Oncology Symptom Experience (PQ Response) randomized controlled trial (RCT).

Main Methods:

  • A multicenter, open-label RCT involving children aged 2+ with advanced cancer.
  • Participants were randomized to PQ Response or usual care for 16 weeks.
  • Weekly HRQOL and symptom surveys were administered to parents and children (aged 5+).

Main Results:

  • Parents in the PQ Response group reported greater improvements in child HRQOL (PedsQL total score: 3.45 points, P=.023).
  • Physical HRQOL scores showed significant improvement, but effects did not consistently exceed the minimal clinically important difference (MCID).
  • No significant improvements were observed in psychosocial HRQOL or symptom scores; however, sensitivity analyses indicated some symptom score improvements exceeding MCIDs.

Conclusions:

  • Integrating ePRO feedback and SPPC shows potential benefits for pediatric advanced cancer care.
  • Enhanced implementation strategies are necessary to optimize the clinical impact of these combined interventions.
  • The study highlights the need for tailored approaches to improve HRQOL in pediatric oncology patients.