Related Experiment Video
Updated: May 11, 2026

11:20
Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Acquired retinoschisis with giant outer layer break and retinal detachment
Fabrizio Giansanti1, Alice Bitossi, Giovanni Giacomelli
1Department of Specialistic Surgical Sciences, Eye Clinic, University of Florence, Viale Morgagni 85, Florence, Italy. fabrizio.giansanti@unifi.it
European Journal of Ophthalmology
|May 28, 2013
Summary
A case of retinoschisis with a giant outer layer break and retinal detachment showed spontaneous resolution without intervention. Non-treatment of nonprogressive retinoschisis-detachment is safer than surgical or prophylactic methods.
Area of Science:
- Ophthalmology
- Retinal Diseases
Background:
- Retinoschisis, a condition causing splitting of the retina, can present with outer layer breaks and associated retinal detachment.
- Giant outer layer breaks in retinoschisis are a significant finding that warrants careful evaluation.
Observation:
- A 42-year-old patient presented with a paracentral scotoma due to inferotemporal retinoschisis-detachment with a giant outer retinal layer break.
- The fovea and internal retinal layer were unaffected, and no treatment was initially advised.
Findings:
- Over a 3-year follow-up, spontaneous reabsorption of subretinal fluid occurred.
- Visual acuity remained stable, indicating a favorable natural history in this specific case.
Implications:
- Conservative management (non-treatment) may be a viable and less risky option for select cases of nonprogressive retinoschisis-detachment.
- This case highlights the potential for spontaneous resolution and stable visual outcomes, challenging the necessity of aggressive interventions in all instances.
More Related Videos
Related Concept Videos
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

