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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
Tricky brucellosis
Mojtaba Hedayat Yaghoobi1, Bahaoddin Siroos, Morteza Foroumandi
1Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
BMJ Case Reports
|May 28, 2013
Summary
Brucellosis, a bacterial infection, can cause serious neurological and cardiac issues. Prompt diagnosis and a 9-month antibiotic regimen led to a full recovery in a young woman with these complications.
Area of Science:
- Infectious Diseases
- Neurology
- Cardiology
Background:
- Brucellosis is a zoonotic bacterial infection with a wide range of clinical manifestations.
- Neurological and cardiac involvement in brucellosis can lead to significant morbidity.
Observation:
- A 23-year-old woman presented with fever, palpitations, myalgia, and transient left-sided hemiparesis.
- Echocardiography revealed myopericarditis, and a comprehensive work-up was initiated.
- Brucellosis was confirmed via bone marrow aspiration culture.
Findings:
- The patient received a 9-month antibiotic regimen including doxycycline, rifampin, and trimethoprim-sulfamethoxazole.
- Complete resolution of neurological and cardiac symptoms was observed post-treatment.
Implications:
- This case highlights the importance of considering brucellosis in the differential diagnosis of unexplained fever, neurological deficits, and cardiac inflammation.
- Aggressive and prolonged antibiotic therapy is crucial for managing complex brucellosis cases.
- Early diagnosis and treatment can prevent long-term neurological and cardiac sequelae.
