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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-II: Pathophysiology and Classification01:26

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Related Experiment Video

Updated: May 11, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

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Published on: October 22, 2020

Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation.

T Nagasaki1, H Matsumoto, H Nakaji

  • 1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|May 29, 2013
PubMed
Summary
This summary is machine-generated.

Smoking may prevent age-related decreases in immunoglobulin E (IgE) and sustain eosinophilic inflammation in asthma patients. Thymic stromal lymphopoietin (TSLP) might play a role in this process.

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Published on: May 30, 2020

Area of Science:

  • Respiratory Medicine
  • Immunology
  • Environmental Health

Background:

  • Smoking is linked to increased risk of atopy and asthma.
  • The impact of smoking on atopy and eosinophilic inflammation in asthmatics, especially the elderly, is not well understood.

Purpose of the Study:

  • To investigate the effects of smoking on serum immunoglobulin E (IgE) levels and eosinophilic inflammation in asthmatics of all ages.

Main Methods:

  • Cross-sectional study of 307 steroid-naive asthmatics.
  • Assessed associations between serum IgE, blood eosinophils, fractional exhaled nitric oxide (FeNO), smoking, and age.
  • Analyzed sputum eosinophils and thymic stromal lymphopoietin (TSLP); excluded current smokers for FeNO analysis.

Main Results:

  • In never-smokers, IgE, blood eosinophils, and FeNO decreased with age. Current smokers did not show decreased IgE with age and had higher blood eosinophils.
  • Ex-smokers showed less steep age-related IgE decline and higher eosinophils/FeNO compared to never-smokers.
  • Sputum TSLP levels correlated with sputum eosinophils and pack-years; smokers had higher TSLP.

Conclusions:

  • Smoking may hinder age-related IgE reduction in asthmatics.
  • Smoking appears to sustain eosinophilic inflammation in asthma.
  • TSLP may be implicated in smoking-related inflammation in asthma.