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Related Experiment Video

Updated: May 11, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Enteroviral myocarditis in neonates.

Luregn J Schlapbach¹, Joerg Ersch, Christian Balmer

¹Paediatric Intensive Care Unit, Mater Children's Hospital, Brisbane, Queensland, Australia.

Journal of Paediatrics and Child Health

|May 29, 2013

Summary

Neonatal myocarditis caused by enteroviruses can be fatal. Extracorporeal membrane oxygenation (ECMO) may be life-saving for infants with severe cardiorespiratory failure, but outcomes vary.

Keywords:

coxsackievirus enterovirus extracorporeal membrane oxygenation myocarditis neonate

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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Published on: May 24, 2016

Area of Science:

Pediatrics
Infectious Diseases
Cardiology

Background:

Enteroviruses are common pediatric viral pathogens.
While typically causing mild illness, enteroviruses can lead to severe conditions like myocarditis in neonates.
Neonatal myocarditis presents a significant mortality risk.

Observation:

Two cases of neonatal enteroviral myocarditis are presented.
Both infants experienced cardiorespiratory failure and severe shock unresponsive to standard treatments.
Extracorporeal membrane oxygenation (ECMO) was required for hemodynamic support.

Findings:

One neonate with Coxsackievirus B3 myocarditis died after 3 weeks on ECMO.
The second neonate, supported with ECMO for 9 days, recovered completely after decannulation.
Neonatal myocarditis demonstrates a high mortality rate.

Implications:

Early consideration of ECMO is crucial for neonates with enteroviral myocarditis experiencing rapid clinical and echocardiographic decline.
Aggressive supportive care, including ECMO, may improve outcomes in severe cases.
Further research into the management of neonatal enteroviral myocarditis is warranted.