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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

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Related Experiment Video

Updated: May 11, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

Engineering skeletal muscle repair.

Mark Juhas1, Nenad Bursac

  • 1Department of Biomedical Engineering, Duke University, 3000 Science Drive, Hudson Hall Room 136, Durham, NC 27708, USA.

Current Opinion in Biotechnology
|May 29, 2013
PubMed
Summary
This summary is machine-generated.

Skeletal muscle regeneration is key to restoring function. This research explores using myogenic stem cells, biomaterials, and tissue engineering for muscle repair therapies.

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Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
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Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis

Published on: August 24, 2017

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
07:13

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

Published on: October 7, 2016

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Last Updated: May 11, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
09:17

Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis

Published on: August 24, 2017

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
07:13

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

Published on: October 7, 2016

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cell Biology

Background:

  • Skeletal muscle possesses significant regenerative capacity, involving new cell formation and network re-establishment.
  • Impaired muscle regeneration necessitates strategies to restore muscle mass and function.
  • Understanding muscle self-repair is crucial for developing effective therapeutic interventions.

Purpose of the Study:

  • To describe current strategies for restoring diseased or injured muscle function.
  • To explore the use of myogenic stem cells, biomaterials, and tissue engineering for muscle repair.
  • To discuss future applications of human cell sources in clinical therapies and disease models.

Main Methods:

  • Review of current approaches in regenerative medicine for skeletal muscle.
  • Integration of myogenic stem cells with biomaterials.
  • Development of functional tissue-engineered muscle constructs.
  • Exploration of human cell sources for therapeutic development.

Main Results:

  • Combined use of myogenic stem cells, biomaterials, and tissue engineering shows promise for muscle restoration.
  • Advancements in tissue engineering enable the creation of functional muscle.
  • Human cell sources offer potential for personalized therapies and in vitro disease modeling.

Conclusions:

  • Regenerative strategies combining cell therapy and biomaterials can restore muscle function.
  • Tissue-engineered muscle holds potential for treating muscle loss and injury.
  • Future research on human cell sources will advance clinical therapies and disease modeling for muscle conditions.